| fmyykjo | Дата: Понедельник, 02.03.2015, 17:16 | Сообщение # 1 |
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Группа: Гости
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Daptomycin is a cyclic lipopeptide antibiotic produced close to the organism Streptomyces roseosporus.[14 - [15 - Daptomycin consists of thirteen amino acids, ten of which are arranged in a cyclic manner, and three that adorn an exocyclic tail. Two non-proteinogenic amino acids exist in the lipopeptide, the uncommon amino acid L-kynurenine (Kyn), however known to Daptomycin, and L-3-methylglutamic acid (mGlu). The N-terminus of the exocyclic tryptophan remainder is coupled to decanoic acid, a standard manacle (C10) fatty acid. Biosynthesis is initiated by the coupling of decanoic acid to the N-terminal tryptophan, followed not later than the coupling of the unused amino acids aside nonribosomal peptide synthetase (NRPS) mechanisms. In the end, a cyclization at any rate occurs, which is catalyzed by way of a thioesterase enzyme, and ensuing release of the lipopeptide is granted.
The non-ribosomal peptide synthetase (NRPS) responsible for the fusion of Daptomycin is encoded by three overlapping genes, dptA, dptBC and dptD. The dptE and dptF genes, immediately upstream of dptA, are favoured to be snarled in the initiation of daptomycin biosynthesis during coupling decanoic acid to the N-terminal Trp.[16 - These novella genes (dptE, dptF ) correspond to products that most qualified trade in conjunction with a unique condensation specialization to acylate the from the start amino acid (tryptophan). These and other novella genes (dptI, dptJ) are believed to be involved in supplying the non-proteinogenic amino acids L-3-methylglutamic acid and Kyn; they are located next to the NRPS genes.[16 -
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